Dr. Amer Elias
Rewriting the Genome, Redesigning Gene Therapy
Our laboratory develops precise and programmable genome-engineering technologies for the treatment of hereditary diseases, cancer, and neurological disorders. We combine site-specific tyrosine recombinases with CRISPR-based systems to enable the safe insertion, replacement, and regulation of large DNA sequences while minimizing double-strand breaks and unwanted genomic changes. By integrating molecular biology, protein engineering, mammalian cell models, and high-throughput screening, we aim to translate innovative genome-editing platforms into new gene and cell therapy strategies.
