Assoc. Prof. Sarit Sivan

1. Sivan S, Lotan N. Modification of hemoglobin with NAD-based molecules: design and synthesis. Proceedings of the International Journal of Artificial Organs, Italy, 1998, 21(10):600.
2. Sheskin T, Sivan S, Geyer O, Lotan N. Controlled release of local anesthetics from biodegradable and eye-injectable nanoparticles. XXIVth Annual Meeting Israeli Society for Vision and Eye Research. Israel, 2004, p. 88.
3. Sivan S, Tsitron E, Roughley P, DeGroot J, Verzijl N, Bank RA, Maroudas A. Turnover of human disc constituents using aspartic acid as a marker of molecular age. XIXth Annual Federation of European Connective Tissue Society, FECTS Meeting, Italy, July, 2004.
4. Rougley PJ, Melching L, Mort JS, Pearce RH, Sivan S, Maroudas A. The structure, degradation and life-span of aggrecan in the human intervertebral disc. European Cells and Materials, ECM VI, Switzerland, 2005, 10(3):17.
5. Sivan S, Tsitron E, Roughley P, DeGroot J, Verzijl N, Bank RA, Merkher Y, Maroudas A. Racemization of aspartic acid and non-enzymatic glycation of human intervertebral disc constituents as measures of turnover. 51st Annual Meeting of the Orthopedic Research Society, ORS, Washington D.C. February, 2005.
6. Roughley PJ, Melching LI, Sivan S, Tsitron E, Maroudas A, DeGroot J, Mort JS. The origin of proteoglycans heterogeneity in the human intervertebral disc. 51st Annual Meeting of the Orthopaedic Research Society, ORS, Washington D.C. February, 2005.
7. Merkher Y, Sivan S, Halperin G, Nahir M, Etsion I, Nitzan D, Barenholtz Y. Effect of active additives on the friction of human articular cartilage. World Tribology Congress-III, Washington D.C. September, 2005.
8. Schroeder A, Sivan S, Merkher Y, Rahamim E, Diminisky D, Priev A, Yosef A, Maroudas A, Halperin G, Barbur A, Nitzan D, Etsion I, Barenholz Y. Liposomes as potential biolubricant and wear reduction in human synovial joints. International Society of Liposomes (ISL), London, December, 2006.
9. Schroeder Y, Sivan S, Wilson W, Huyghe A, Maroudas A, Baaijens FPT. Intra- and extrafibrillar exchange in the disc. Proceeding of the ASME Summer Bioengineering Conference (SBC2007-176329), Keystones, Colorado, June 2007, pp. 367-368.
10. Schoroeder A, Verberne G, Merkher Y, Diminsky D, Maroudas A, Halperin G, Nitzan D, Etsion I, Barenholz Y, Sivan S. Surface active phospholipids as cartilage lubricants. ASME 2008 9th Biennial ASME Conference on Design and Analysis (ESDA2008), Proc. ASME ESDA. Israel, 2008, pp. 549-553.
11. Bramhill JH, Tighe BJ, Campbell DC, Lydon F, Urban J, Roberts S, Sivan S. A sulphonate based hydrogel for nucleus pulposus repair. 23rd European Society for Biomaterials, ESB2010. Finland, September, 2010.
12. Boubriak OA, Stubben N, Watson S, Sivan S, Urban JPG. Bovine caudal discs: relationship between disc height, cell density and blood supply. International Society for the Study of the Lumbar Spine, ISSLS, Sweden, June, 2011.
13. Jung MC, Dcharm M, Heinz A, Pankau R, Wohlrab J, Sivan S, Merkher Y, Maroudas A, Neubert RHH, Schmeltzer CEH. Molecular comparison of elastins from different human tissues. Gordon Research Conference (GRC) Elastin & Elastic Fibers, Biddeford, ME, USA, July 2011.
14. Sivan S, Roberts S, Urban JP, Menage J, Bramhill J, Campbell D, Franklin V, Lydon F, Merkher Y, Maroudas A, Tighe B. Injectable hydrogels with high fixed charge density and swelling pressure for nucleus repair: biomimetic glycosaminoglycan analogues. The 2nd Conference of the Israel Society for Biotechnology Engineering (ISBE) Tel-Aviv, December, 2013.

Abstracts

1. Sivan S, Lotan N. Enzyme-based molecular logic systems. Annual meeting of the Israeli Society of Medical and Biological Engineering (ISMBE), Israel, September, 1993.
2. Tzor O, Sivan S, Lotan N. Immobilized biochemical systems: design and optimization of their spatial arrangement. 5th Annual meeting of the Israeli Chapter of the Controlled Release Society, ICRS, Israel, September, 2004.
3. Schroeder A, Sivan S, Merkher Y, Rahamim E, Diminisky D, Priev A, Yosef A, Maroudas A, Halperin G, Barbur A, Nitzan D, Etsion I, Barenholz Y. Liposomes as potential biolubricant for friction and wear reduction in human synovial joints. Israeli Controlled Release Society, ICRS, Caesarea, September 2007.
4. Sivan S, Lotan N, Dinnar U. Drug factories on stents. Innovations in Cardiovascular Innovations, ICI, Tel-Aviv, December, 2007.
5. Etsion I, Verbene G, Schroeder A, Sivan S, Merkher Y, Halperin G, Maroudas A, Barenholz Y. Phospholipid liposomes as potential biolubricants agents for friction and wear reduction in cartilage of human synovial joints: The role of phospholipid physical chemistry and nanoism. Soft Matter at Interfaces: From Self Assembly to Nano-Confiment. Neve Ilan, June, 2009.
6. Alagem M, Sivan S, Flugelman M, Beyar R, Dinnar U, Lotan N. Targeted delivery at stent surface of in-situ produced drugs: A novel therapeutic approach. 17th International LDDR – Local Drug Delivery meeting and cardiovascular course on Revascularization (LDDR) and Molecular Strategies. Geneva, February, 2010.
7. Ne’eman N, Marbach D, Chen-Konak L, Kaufman-Francis K, Berkovich M, Levenberg S, Lotan N, Sivan S. Sequential multi-factorial releasing scaffolds for tissue engineering: fabrication by the solvent/non-solvent sintering technology. 7th Israeli Chapter of Controlled Release Society, Haifa, October 2010.
8. Alagem M, Sivan S, Flugelman M, Beyar R, Dinnar U, Lotan N. A novel therapeutic approach: drug factories on stent. Israeli Heart Society (IHS), Haifa, Israel, February, 2010.
9. Alagem M, Kivovich E, Lanir N, Zchori I, Falah M, Sivan S, Flugelman M, Beyar R, Dinnar U, Lotan N. Therapeutically-active implants exhibiting improved biocompatibility: an ex vivo study. Israeli Society for Medical and Biological Engineering, ISMBE, Afeka, February, 2011.
10. Boubriak OA, Watson N, Sivan S, Stubbens N, Lee RB, Urban JPG. Cell density of the intervertebral disc is regulated by blood supply, BSMS, Bristol, UK, April, 2011.
11. Schmelzer CEH, Jung MC, Sivan S, Scharm M, Pankau R, Neubert RHH, Heinz A. Molecular insights into alterations of elastic fibers, 7th European Elastin Meeting, September 2012, Ghent, Belgium.
12. Nagel MBM, Heinz A, Sivan S, Pankau R, Neubert RHH, Schmelzer CEH. Insights into the proline hydroxylation of elastin derived from different tissues and species, 7th Polish-German Symposium on Pharmaceutical Sciences, Gdańsk, May, 2013.
13. Alagem M, Kivovich E, Tzchori I, Lanir N, Falah M, Flugelman M, Dinnar U, Beyar R, Lotan N, Sivan S. Bio-inspired implants for the treatment of restenosis. 10th OBC Research Day, Nahariya, October, 2014.
14. Alagem M, Kivovich E, Tzchori I, Lanir N, Falah M, Flugelman M, Dinnar U, Beyar R, Lotan N, Sivan S. Bio-inspired, enzymatically active, anti-restenotic/anti-thrombotic carrier. BIT’s 5th World Gene Convention-2014 (WGC-2014), Theme: Olympic Campaign of New Biotechnology¸ Co-Chair: Path 6: Biocatalysis and biotransformation and scale up of bioprocesses, Haikou, China, November 2014.
15. Benguigui M, Weitz IS, Timaner M, Kan T, Shechter D, Sivan S, Raviv Z, Azhari H Shaked Y. Copper oxide nanoparticles inhibit pancreatic tumor growth by targeting tumor initiating cells. 17th Biennial Congress of the Metastasis Research Society and Young Investigator Satellite Meeting. Princeton University, August 2018.
16. Weitz IS, Perlman O, Sivan S, and Azhari H, Synthesis and characterization of copper oxide based polymeric nano-systems for biomedical imaging, CIMTEC 2018, 8th Forum on New Materials, Perugia, Italy, June, 2018.
17. Weitz IS, Sivan S, Perlman O, Azhari H. Preparation of PLGA nanospheres as carriers for copper oxide nanoparticles based imaging contrast agent. BioNanoMed 2019.

Invited Talks/Colloquia

2004 – Major biochemical components of the intervertebral disc, their turnover and some functional properties. Annual EuroDisc Meeting: Institut für Unfallchirurgische Forschung und Biomechanik, Universität Ulm, Germany.
2005 – Correlation of swelling pressure, intra-fibrillar water and collagen tensile in young and aged human intervertebral discs. Annual EuroDisc Meeting: Department of Biomedical Engineering, University of Eindhoven, The Netherlands.
2005 – Turnover of the major components of the intervertebral disc. Annual EuroDisc Meeting: University of Warwick, England.
2007 – Biomimetic approach to nucleus disc replacement and repair. University of Oxford, England.
2008 – Tissue turnover and matrix degradation: production and role of matrix fragments. Annual GenoDisc Meeting: Istituto Ortopedico Galeazzi, Milan, Italy.
2009 – A needle micro-osmomter for measurement of glycosaminoglycans. Annual GenoDisc Meeting: Institute of Biology NCSR Demokritos, Athens.
2010 – Determination of the turnover of collagen, aggrecan and elastin in the human intervertebral disc using aspartic acid. Annual GenoDisc Meeting: Budapest, National Center for Spinal Disorders, Buda Health Center.
2013 – Structure, degeneration and repair of intervertebral disc. Department of Biomedical Engineering, Technion, IIT, Haifa, Israel.
2013 – Biomimetic approach to repair of cartilaginous tissues. Institute of Pharmacy, Biosciences, Martin Luther University, Halle-Wittenberg, Germany.
2013 – Biologically-inspired materials for connective tissue repair. Annual Research Conference, ORT Braude College.
2019 – Liposomes as effective biolubricants for friction, wear and pain reduction in human synovial joints. Annual Research Conference, ORT Braude College.

Patents