Assoc. Prof. Sarit Sivan

Assoc. Prof. Sarit Sivan

Assoc. Prof. Sarit Sivan

04-9901855
M
מחלקה: Biotechnology Engineering
תפקיד נוכחי: Vice President for Academic Affairs

Education :

Ph.D. 2000, Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel

M.Sc. 1995, Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel

B.Sc. 1992, Biology (Cum Laude), Technion-Israel Institute of Technology, Haifa, Israel

Research Interests
  • 1. Biomaterials and biomemetic for tissue regeneration and replacement of intervertebral disc and cartilage
  • 2. Biophysics of connective tissue in health, pathology and ageing
  • 3. Lubrication in synovial joints
  • 4. Multi-functional systems for tissue engineering and drug delivery
  • 5. Immobilization of biomolecules
Courses
  • 1. Engineering Principles in Biology and Biotechnology
  • 2. Molecular Engineering
  • 3. Methods in Biochemical Engineering
  • 4. Methods in Biomaterial Engineering
  • 5. Technologies in Cells and Tissue Engineering (Course and Lab)
  • 6. Metabolism and Enzymology (Lab course)
  • 7. Methods in Separation and Diagnostics (Lab course)
  • 8. Scientific Writing

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Refereed Papers

 1. Sivan S, Lotan N. A biochemical logic gate using an enzyme and its inhibitor.1. The inhibitor  as switching element. Biotechnol Prog (1999) 15(6):964-70. (Invited paper).

2. Sivan S., Lotan N. Molecular Engineering of Proteins with Predefined Function: Part I: Design  of hemoglobin-based oxygen carrier. Biomol Eng (2003) 20(3):83-90.

3. Sivan S, Lotan N. A biochemical logic gate using an enzyme and its inhibitor. 2. The logic  gate.  BioSystems (2003) 70(1):21-33.

4. Filo O, Guzy S, Sivan S, Sideman S, Lotan N. Process analysis of a reactor-separator system: enzymic degradation of polymeric substrates. Isr J Chem (2005) 45(4):495-505.

5. Sivan S, Neidlinger-Wilke C, Wurz K, Maroudas A, Urban JPG. Diurnal fluid expression and  activity in intervertebral disc cells. Biorheology (2006) 43(3-4):283-291. (Invited Review).

6. Sivan S, Wachtel E, Merkher Y, Maroudas A. Correlation of swelling pressure and intra- fibrillar water in young and aged annuli of human intervertebral discs. J Orthop Res (2006) 24(6):1292-8.

7. Sivan S, Tsitron E, Wachtel E, Roughley P, Sakkee AN, van-der Ham F, DeGroot J, Roberts S,  Maroudas A. Aggrecan turnover in human intervertebral disc as determined by the  racemization of aspartic acid. J Biol Chem (2006) 281(19):13009-14.

8. Merkher Y, Sivan S, Etsion I, Maroudas A, Halperin G, Yosef A. A rational human joint  friction test using a human cartilage-on-cartilage arrangement. Tribol Lett (2006) 22(1):29-36.

9. Sivan S, Tsitron E, Wachtel E, Roughley P, Sakkee N, van der Ham F, DeGroot J, Merkher Y,  Maroudas A. Age-related accumulation of pentosidine in aggrecan and collagen from human  intervertebral disc. Biochem J (2006) 398(1):29-35.

10. Johnson WEB, Sivan S, Wright KT, Eisenstein SM, Maroudas A, Roberts S. Human  intervertebral disc cells promote nerve growth over substrata of human intervertebral disc  aggrecan. Spine (2006) 31(11):1187-93. (Invited paper).

11. Sivan S, Filo O, Siegelmann H. Application of expert networks for predicting proteins  secondary structure. Biomol Eng (2007) 24(2):237-43.

12. Schroeder Y, Sivan S, Wilson W, Huyghe JM, Merkher Y, Maroudas A. Baaijens FPT. Are disc  pressure, stress and osmolarity affected by intra- and extrafibrillar fluid exchange? J Orthop  Res(2007) 25(10):1317-43.

13. Sivan S, Wachtel E, Tsitron E, Sakkee AN, van-der Ham F, DeGroot J, Maroudas A. Collagen  turnover in healthy and pathological human intervertebral disc as determined by the  racemization of aspartic acid. J Biol Chem (2008) 283(14):8796-801.

14.  Roberts S, Menage J, Sivan S, Urban JPG. Bovine explant model of degeneration of the  intervertebral disc. BMC Musculoskelet Disord (2008) 9(1):24.

15.  Sivan S, Schroeder A, Verberne G, Merkher Y, Diminsky D, Priev A, Maroudas A, Halperin G,  Nitzan D, Etsion I, Barenholz Y. Liposomes act as effective biolubricants for friction reduction  in human synovial joints. Langmuir (2010) 26(2):1107-16.

16.  Boubriak O, Watson N, Sivan S, Stubbens N, Lee RB, Urban JPG. Cell density of the  intervertebral disc is regulated by blood supply. Int J Exp Path (2011) 92(6):A14-A15.

17.  Sivan S, Merkher Y, Wachtel E, Van El B, Zuurmund AM, Schmeltzer C, Heinz, A, Varga PP,  Lazary A, Brayda M, Maroudas A. Longevity of elastin in human intervertebral disc as probed  by the racemization of aspartic acid. Biochim Biophys Acta (2012) 1820(10):1671-7.

18.  Boubriak OA, Watson N, Sivan S, Stubbens N, Lee RB, Urban JPG. Factors regulating viable  cell density in the intervertebral disc: blood supply in relation to disc height. J Anat (2013)  222(3):341-8.

19.  Sivan S, Merkher Y, Wachtel E, Urban JPG, Lazary A, Maroudas A. A needle micro- osmometer for determination of glycosaminoglycan concentration in excised nucleus pulposus  tissue. Eur Spine J (2013) 22(8):1765-73.

20.  Ne’eman N, Marbach D, Chen-Konak L, Kaufman-Francis K, Berkovich M, Levenberg S, Lotan  N, Sivan S. Multi-factor, sequentially releasing scaffolds for tissue engineering: Fabrication by  the novel solvent/non-solvent sintering technology. Isr J Chem (2013) 53:821-8. (Invited paper).

21.  Brayda-Bruno M, Tibiletti M, Ito K, Fairbank J, Galbusera F, Zerbi A, Roberts S, Wachtel E,  Merkher Y, Sivan S. Advances in the diagnosis of degenerated discs and their possible clinical  applications. Eur Spine J (2014) 3:315-23.

22.  Sivan S, Hayes A, Wachtel E, Caterson B, Merkher Y, Brown S, Maroudas A., Roberts, S.  Biochemical composition and turnover of the extracellular matrix of the normal and degenerate  intervertebral disc. Eur Spine J (2014) 23(3):344-353.

23.  Sivan S, Roberts S, Urban JP, Menage J, Bramhill J, Campbell D, Franklin V, Lydon F, Merkher  Y, Maroudas A, Tighe B. Injectable hydrogels with high fixed charge density and swelling  pressure for nucleus repair: biomimetic glycosaminoglycan analogues. Acta Biomater (2014)  10(3):1124-1133.

24.  Alagem M, Kivovich E, Tzchori I, Falah M, Flugelman M, Lanir N, Beyar R, Lotan N, Sivan S.  The formation of an anti-restenotic/anti thrombotic surface by immobilization of nitric oxide  synthase. Acta Biomater (2014) 10(5):2304–2312.

25.  Sivan S, Wachtel E, Roughley P. Structure, function, ageing and turnover of aggrecan in the  intervertebral disc. Biochim Biophys Acta (2014) 1840(10):3181-3189.

26. Schmelzer CHE, Nagel M, Dziomba S, Merkher Y, Sivan S, Heinz A. Prolyl hydroxylation in  elastin is not random. Biochim Biophys Acta (2016).

Books
Book Chapters
  1. Sivan, S., Lotan, N. (2006). Artificial Blood. In: Wiley Encyclopedia of Biomedical Engineering (Akay, M. Ed.) 1:130-143.
  2. Wilke, CN., Urban, JPG., Roberts, S., Maroudas, A., Sivan, S., Kletsas, D., Videman, T., Huyghe, J. (Wilke, A.J. Ed.). (2006). Why Do Intervertebral Discs Degenerate? Presentation of the European Research Project EURODISC. In: Proceeding of the Ergo Mechanics 2, Shaker-Verlag GMBH (Germany) 124-137.
  3. Sivan S, Maroudas A, Wachtel E. (Casado-Zapico S. Ed). (2016)Aspartic acid racemization in cartilaginous tissues, In: Mechanisms Linking Aging, Diseases and Biological Age Estimation. Springer. CRC Press. ISBN 9781498709699.

Conference Proceedings and Abstracts

  1. Sivan, S., Lotan, N. Modification of hemoglobin with NAD-based molecules: design and synthesis. International Journal of Artificial Organs, Italy, 1998, 21(10):600.
  2. Sheskin, T., Sivan, S., Geyer, O., Lotan N. Controlled release of local anesthetics from biodegradable and eye-injectable nanoparticles. XXIVth Annual Meeting Israeli Society for Vision and Eye Research. Israel, 2004, 88.
  3. 3.     Rougley, PJ., Melching, L., Mort, JS., Pearce, RH., Sivan, S., Maroudas, A. The structure, degradation and life-span of aggrecan in the human intervertebral disc. European Cells and Materials, ECM VI, Switzerland, 2005, 10(3):17.
  4. 4.     Neidlinger-Wilke, C., Urban, J.P.G., Roberts, S., Maroudas, A., Sivan, S., Kletsas, D., Videman, T., Battie, M. & Huyghe, J.M.R.J. Why do intervertebral discs degenerate? Presentation of the European research project EURODISC. Ergomechanics 2. Interdisciplinary conference on spinal column research, Germany, 2006, 124-137 (Shaker Verlag).
  5. 5.     Schroeder, Y., Sivan, S., Wilson, W., Huyghe, A., Maroudas, A., Baaijens, FPT. Intra- and extrafibrillar exchange in the disc. Proceeding of the ASME Summer Bioengineering Conference (SBC2007-176329), pp. 367-368, Keystones, Colorado, June, 2007.
  6. 6.     Schoroeder, A., Verberne, G., Merkher, Y., Diminsky, D., Maroudas, A., Halperin, G., Nitzan, D., Etsion, I., Barenholz, Y. Sivan, S.  Surface active phospholipids as cartilage lubricants. ASME 2008 9th Biennial ASME Conference on Design and Analysis (ESDA2008), Proc. ASME ESDA. Israel, 2008, (3):549-553.
  7. Bramhill, JH., Tighe, BJ., Campbel, DC., Lydon, F., Urban, J., Roberts, S., Sivan, S. A sulphonate based hydrogel for nucleus pulposus repair. 23rd European Society for Biomaterials, ESB2010. Finland, 2010, 57.

Abstracts

  1. Sivan, S., Lotan, N. Enzyme-based molecular logic systems. Annual. Meeting Israeli Society of Medical and Biological Engineering, Israel, September, 1993.
  2. Sivan, S., Tsitron, E., Roughley, P., DeGroot, J., Verzijl, N., Bank, RA., Maroudas, A. Turnover of  human disc constituents using aspartic acid as a marker of molecular age. XIXth Annual Federation of European Connective Tissue Society, FECTS Meeting, Italy, July, 2004.
  3. Tzor, O., Sivan, S., Lotan, N. Immobilized biochemical systems: design and optimization of their spatial arrangement. 5th Annual meeting of the Israeli Chapter of the Controlled Release Society, ICRS, Israel, September, 2004.
  4. Sivan, S., Tsitron, E., Roughley, P., DeGroot, J., Verzijl, N., Bank, RA., Merkher, Y., Maroudas, A. Racemization of aspartic acid and non-enzymatic glycation of human intervertebral disc constituents as measures of turnover. 51st Annual Meeting of the Orthopaedic Research Society, ORS, Washington D.C. February, 2005.
  5. Roughley, PJ., Melching, LI., Sivan, S., Tsitron, E., Maroudas, A., DeGroot, J., Mort, JS. The origin of proteoglycans heterogeneity in the human intervertebral disc. 51st Annual Meeting of the Orthopaedic Research Society, ORS, Washington D.C. February, 2005.
  6. Merkher, Y., Sivan, S., Halperin, G., Nahir, M., Etsion, I., Nitzan, D., Barenholtz, Y. Effect of active additives on the friction of human articular cartilage. World Tribology Congress-III, Washington D.C., September, 2005.
  7. Schroeder, A., Sivan, S., Merkher, Y., Rahamim, E., Diminisky, D., Priev, A., Yosef, A., Maroudas, A., Halperin, G., Barbur, A., Nitzan, D., Etsion, I., Barenholz, Y. Liposomes as potential biolubricant and wear reduction in human synovial joints. International Society of Liposomes, ISL, London, December, 2006.
  8. Schroeder, A., Sivan, S., Merkher, Y., Rahamim, E., Diminisky, D., Priev, A., Yosef, A., Maroudas, A, Halperin, G., Barbur, A., Nitzan, D., Etsion, I., Barenholz, Y. Liposomes as potential biolubricant for friction and wear reduction in human synovial joints. Israeli Controlled Release Society, ICRS, Caesarea, September 2007.
  9. Etsion, I., Verbene, G., Schroeder, A., Sivan, S., Merkher, Y., Halperin, G., Maroudas, A., Barenholz, Y. Phospholipid liposomes as potential biolubricants agents for friction and wear reduction in cartilage of human synovial joints: The role of phospholipid physical chemistry and nanoism. Soft Matter at Interfaces: From Self Assembly to Nano-Confiment. Neve Ilan, June, 2009.
  10. Alagem, M., Sivan, S., Flugelman, M., Beyar, R., Dinnar, U., Lotan, N. Targeted delivery at stent surface of in-situ produced drugs: A novel therapeutic approach. 17th International LDDR – Local Drug Delivery meeting and cardiovascular course on Revascularization & molecular strategies. Geneva, February, 2010.
  11. Alagem, M., Sivan, S., Flugelman, M., Beyar, R., Dinnar, U., Lotan, N. A novel therapeutic approach: drug factories on stent. Israeli Heart Society. Haifa, Israel, February, 2010.
  12. Alagem, M., Kivovich, E., Lanir, N., Zchori, I., Falah, M., Sivan, S., Flugelman, M., Beyar, R., Dinnar, U., Lotan, N. Therapeutically-active implants exhibiting improved biocompatibility: an ex vivo study. Israeli Society for Medical and Biological Engineering, ISMBE, Afeka, February, 2011.
  13. Boubriak, OA., Watson, N., Sivan, S., Stubbens, N., Lee, RB., Urban, JPG . Cell density of the intervertebral disc is regulated by blood supply, BSMS, Bristol, UK, April, 2011.
  14. Boubriak, OA., Stubben, N., Watson, S., Sivan, S., Urban, JPG. Bovine caudal discs: relationship between disc height, cell density and blood supply. International Society for the Study of the Lumbar Spine, ISSLS, Sweden, June, 2011.
  15. Sivan, S., Lotan, N. and Dinnar, U. Drug factories on stents. Innovations in Cardiovascular Innovations, ICI, Tel-Aviv, December, 2007.
  16. Jung, MC., Dcharm, M., Heinz, A., Pankau, R., Wohlrab, J., Sivan, S., Merkher, Y., Maroudas, A., Neubert, RHH., Schmeltzer, CEH. Molecular comparison of elastins from different human tissues. Gordon Research Conferences Elastin and Elastic Fibers, New Hampshire, USA, July, 2011.
  17. Schmelzer, CEH., Jung, MC., Sivan, S., Scharm, M., Pankau, R., Neubert, RHH., Heinz, A. Molecular insights into alterations of elastic fibers, 7th European Elastin Meeting, Sept, 2012, Ghent, Belgium.
  18. Nagel, MBM., Heinz, A., Sivan, S., Pankau, R., Neubert, RHH., Schmelzer, CEH. Insights into the proline hydroxylation of elastin derived from different tissues and species, 7th Polish-German Symposium on Pharmaceutical Sciences, Gdańsk, May 24-25, 2013.
  19. Sivan S, Roberts S, Urban JP, Menage J, Bramhill J, Campbell D, Franklin V, Lydon F, Merkher Y, Maroudas A, Tighe B. Injectable hydrogels with high fixed charge density and swelling pressure for nucleus repair: biomimetic glycosaminoglycan analogues. The 2nd Conference of the Israel Society for Biotechnology Engineering (ISBE) Tel-Aviv, December, 2013.
  20. Alagem M, Kivovich E, Tzchori I, Lanir N, Falah M, Flugelman M, Dinnar U, Beyar R, Lotan N, Sivan S.Bio-inspired implants for the treatment of restenosis. 10th OBC Research Day, Nahariya, October, 2014.

Other Publications

Theses
Ph.D. 2000, “Molecular engineering of bioactive materials with predefined specificity: design and synthesis of hemoglobin derivatives”, Department of Biomedical Engineering, Technion (Supervisors: Prof. N. Lotan and Prof. R. Beyar).

M.Sc. 1995, “Biochemical logic systems for molecular electronics: enzyme-based systems”, Department of Biomedical Engineering, Technion (Supervisor: Prof. N. Lotan).

Patents

  1. Sivan, S., Dinnar, U., Lotan, N. Intravascular apparatus and method. (2003) US Pat 6569688.
  2. Sivan, S., Merkher, Y., Maroudas, A. A micro device for in vivo and in situ measurements in cartilaginous tissues (2011) US61/633571.
  3.  Molinari, M., Coussios, CC., Gibbons, DS., Arora, M., Urban, JP., Sivan, S. Intervertebral disc treatment method and apparatus (2011) Patent Pending.
  4. Sivan, S., Elata, D., Merkher, Y., Maroudas, A. A micro-device for measuring water in vivo and in vitro. (2009) Patent Pending.
  5. Tighe, B., Franklin, V., Lyndon, FJ., Roberts, S., Urban, JP., Sivan, S. Intervertebral disc and intraocular lens. (2008) US20110118379A1.
  6. Barenholz, C., Nitzan, D., Etsion, I., Schroeder, A., Halperin, G. and Sivan, S. Methods for joint lubrication and cartilage wear prevention making use of glycerophospholipids (2006) US 20100098749.

Academic Appointments

2015 (Nov) –    Associate Professor, Department of Biotechnology Engineering, ORT Braude  College, Karmiel, Israel

2013 – present  –   Head, Department of Biotechnology Engineering, ORT Braude College,  Karmiel, Israel

2013 – present   –  Senior Lecturer, Department of Biotechnology Engineering, ORT Braude  College, Karmiel, Israel

2012 – present  –   Adjunct Senior Lecturer, Department of Biomedical Engineering, Technion-IIT,  Haifa, Israel

2008 – 2013    –     Adjunct Senior Research Fellow, Department of Biomedical Engineering,  Technion-IIT, Haifa, Israel

2006 – 2008    –     Postdoctoral Associate, Marie-Curie Fellow, Department of Physiology,  Anatomy and Genetics, University of Oxford, UK

2003 – 2005    –     Postdoctoral Research Fellow, Department of Biomedical Engineering,  Technion-IIT, Haifa, Israel

2001 – 2003    –     Adjunct Lecturer, Department of Biomedical Engineering, Technion-IIT, Haifa,  Israel

2000-2001 Research Fellow, Department of Biomedical Engineering, Technion – Israel  Institute of Technology, Haifa, Israel

1992-2000  –  Teaching and Research Assistant, Department of Biomedical Engineering,  Technion – Israel Institute of Technology, Haifa, Israel

Teaching Experience

Technion – Department of Biomedical Engineering
Engineering Principles in Biology and Biotechnology
Molecular Engineering
Methods in Biochemical Engineering
Methods in Biomaterial Engineering
STUDENT SUPERVISION

Technion – Israel Institute of Technology (M.Sc)

  1. Algem M, (2011) ‘Converging technologies at the interface between natural and artificial bio-systems (with Prof. N. Lotan and Prof. R. Beyar).
  2. Merkher Y, (2006) ‘The Effect of new lubricants on the friction of human cartilage’ (with Prof. I. Etsion and Prof. A. Maroudas).
  3. Ne’eman N, (2006) ‘Biological materials in polymeric matrices: multi-functional systems for Applications in tissue engineering’ (with Prof. N. Lotan).
  4. Langzam-Sinai R, (2006) ‘Neutral and ionizable polymeric hydrogels in biomedical engineering’ (with Prof. Y. Lanir and Prof. N. Lotan).
  5. Tsitron E, (2006) ‘Molecular age and turnover of proteoglycans and collagen of the human intervertebral disc’ (with Prof. A. Maroudas).
  6. Sheskin T, (2005) ‘Polymeric systems for ocular drug delivery’ (with Prof. N. Lotan and Prof. O. Geyer).

Academic and Professional Awards and Grants

2012                Marie-Curie Prize for Innovation and Entrepreneurship

2011-2013       Marie-Curie Re-integration (ERG) Fellowship

2009                Spine Award in Regenerative Technologies for the Intervertebral Disc Biomaterial:

2009 Best New Technology. Sponsored by Orthopedics This Week

2006-2008       Marie-Curie Intra-European (IRG) Fellowship

1999-2000       Archie Micay Biomedical Research Fellowship

1998-1998       Forchheimer Foundation Fellowship

1995-1997       Leonard and Diane Sherman Research Fund Fellowship

1992-1995       Julius and Dorothy Harband Fund Fellowship

1991                Dean’s list, Faculty of Biology, Technion

Professional Activities

Referring for Journals and Conferences

Referring for Journals

2015-present   Osteoarthritis and Cartilage

2013-present   Advanced Drug Delivery Reviews

2013-present   Israel Journal of Chemistry

2012-present   Connective Tissue Research

2012-present   Spine

2011-present   Cartilage

2010-present   Acta Biomaterialia

2007-present   European Spine Journal

Referring for International Conferences

2015                10th World Biomaterial Congress (WBC2016)

2017                Marie Skłodowska-Curie Actions (MSCA) 2017 Conference

Colloquia & Seminar Lectures
  1.     Sivan S. Turnover of aggrecan and collagen in human  intervertebral disc. Mount Sinai School of Medicine (MSSM),  NY, August, 2016.2.      Sivan S. Biologically-inspired materials for connective tissue  repair. ORT Braude College of Engineering, Israel, November,  2013.3.      Sivan S. Biomimetic approach to repair of cartilaginous tissues. Institute of Pharmacy, Biosciences, Martin Luther University, Halle-Wittenberg, Germany, May, 2013.4.      Sivan S. Structure, degeneration and repair of intervertebral  disc. Department of Biomedical Engineering, Technion, Israel,  March, 2013.5.      Sivan S. Determination of the turnover of collagen, aggrecan  and elastin in the human intervertebral disc using aspartic acid.  Budapest, National Center for Spinal Disorders, Buda Health  Center, March, 2010.6.      Sivan S. A needle micro-osmometer for measurement of  glycosaminoglycans. Institute of Biology NCSR Demokritos,  Athens, March, 2009.7.      Sivan S. Tissue turnover and matrix degradation: production  and role of matrix fragments. Istituto Ortopedico Galeazzi,  Milan, Italy, December, 2008.8.      Sivan S. Biomimetic approach to nucleus disc replacement  and repair. University of Oxford, England, May, 2007.9.      Sivan S. Turnover of the major components of the  intervertebral disc. University of Warwick, England,  September, 2005.10.  Sivan S. Correlation of swelling pressure, intra-fibrillar water  and collagen tensile in young and aged human intervertebral  discs. Department of Biomedical Engineering, University of  Eindhoven, The Netherlands, April, 2005.

    11.  Sivan S. Major biochemical components of the intervertebral  disc, their turnover and some functional properties. Institut für  Unfallchirurgische Forschung und Biomechanik, Universität  Ulm, Germany, April, 2004.

Joint Research Projects

2012-present ‘Development of affinity-based methods for the purification of lubricin’, with Prof. Maroudas Alice (Technion) and Prof. Azhari Rosa (ORT Braude College).

2008-present ‘A novel approach for targeted delivery at stent surface of in-situ produced drugs’, with Prof. Dinnar Uri, Prof. Lotan Noah (Technion) and Prof. Beyar Raphael (Rambam Medical Centre).

2008-2013 ‘Disc-degeneration linked pathologies: novel biomarkers and diagnostics for targeting, treatment, prevention and repair’, a participating scientist in the European Union-funded (FP7) consortium, Genodisc (with 10 labs throughout Europe).

2008-2013 ‘A micro osmometer for in-vivo and in-vitro measurement of glycoaminoglycans in intervertebral disc’, with Dr. Urban Jill (Oxford Universty) and Prof. Maroudas Alice (Technion).

2008-present ‘The molecular origin of lubrication in human joints’, with Prof. Maroudas Alice (Technion) and Prof. Klein Jacob (Weizmann Institute of Science, Israel).

2008-present ‘Elastin – structure and function’, with Prof. Winlove Peter (University of Exeter, UK), Prof. Maroudas Alice (Technion, Dr. Schmelzer Chritian (Martin-Luther University, Germany) and Dr. Wachtel Ellen (Weizmann Institute of Science).

2006-present ‘Injectable glycosaminoglycan analogue implant for nucleus pulposus replacement’, with Prof. Tighe Brian (Aston University, UK), Prof. Roberts Sally (Keele University, UK) and Dr. Urban Jill (Oxford University, UK).

2006-2012 ‘High intensity ultrasound as a first step in the repair and replacement of nucleus pulposus in the intervertebral disc’, with Dr. Coussios Constantin and Dr. Urban Jocelyn (Oxford University, UK).

2006-present ‘Liposomes as effective biolubricants for friction reduction in human synovial joints’, with Prof. Barenholz Yechezkel (Hebrew University), Prof. Maroudas Alice (Technion) and Prof. Etsion Izhak (Technion).

2005-2007 ‘Effects of aggrecan on disc cells and sensory nerves’, with Prof. Roberts Sally (Keele University, UK).

2003-2005 ‘Intervertebral disc degeneration: Interplay of age, environmental and genetic factors’, a participating scientist in the European Union-funded (FP6) consortium, Eurodisc (with 7 labs throughout Europe).

Membership in Professional Societies

2016-present   Marie-Curie Alumni Association (MCAA)

2010-present   Israel Society for Medical and Biological Engineering  (ISMBE)

2005-2008       Orthopaedic Research Society (ORS)

2007                 American Society for Biochemistry and Molecular Biology  (ASBMB)

Organizing Committees
Genodisc Meeting– Disc degeneration link-pathologies, Nahsholim Israel, April 2011.
Invited Talks and Keynotes

1.      Sivan S, Novel biomimetic glycosaminoglycan analogues for IVD  repair: Replacing like with like. Computer Methods in Biomechanics  and Biomechanical Engineering (CMBBE) 2016. Tel-Aviv,  September 2016.

2.      Sivan S, Bio-inspired, enzymatically active, anti-restenotic/anti- thrombotic carrier. BIT’s 5th World Gene Convention-2014 (WGC- 2014), Theme: Olympic Campaign of New Biotechnology¸ Co-Chair:  Path 6: Biocatalysis and biotransformation and scale up of  bioprocesses, Haikou, China, November 2014.

3.      Sivan S, Biomimetics for cartilage and disc repair (Keynote).  Winner of the 2012 Marie-Curie Prize. Nicosia, Cyprus, November,  2012.

4.      Sivan S, Sequential multi-factorial releasing scaffolds for tissue  engineering: fabrication by the solvent/non-solvent sintering  technology. 7th Israeli Chapter of Controlled Release Society, Haifa,  October 2010.

5.      Sivan S. Enzyme-based molecular logic systems. Annual Meeting  Israeli Society of Medical and Biological Engineering, Tel Aviv,  September 1993.

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